The new Twitter profile screens are pretty awful, the design itself I can live with, but the silly varying font size is awful!
To put all the fonts back to 14px in size, paste this into the developer console:
$('head').append('<style>.ProfileTweet-text{font-size: 14px !important; line-height: 1.6em !important;}</style>');
This will stick until a page refresh, twitter will sometimes do this, so its not a permanent fix, but hopefully, Twitter will sort this UI out – there are so many complaints around already!
If you are using Chrome, you can add a bookmark to do this at the click of the toolbar – create a new bookmark in Chrome from the bookmark manager (Ctrl+Shift+O) -> Organize -> Add Page, with the title “Smaller Twitter Profile Fonts” and the url as:
javascript: $('head').append('<style>.ProfileTweet-text{font-size: 14px !important; line-height: 1.6em !important;}</style>');
This will make the fonts for your tweets all the same font-size.